The Panthers face significant lineup changes for their game against the Rams, particularly on the offensive line, with ten different combinations in thirteen weeks. Key players out due to injuries, including Horn, Rozeboom, Cherelus, Mays, Renfrow, Harrison-Hunte, and Jackson. The team calls up Saahdiq Charles, Nick Samac, and Yosh Nijman from the practice squad. Defense sees new faces, with Trevin Wallace, Lathan Ransom, and Chau Smith-Wade starting, and Kalen King, Robert Rochell, and Isaiah Simmons joining the team.
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