Can the Jacksonville Jaguars conquer the San Francisco 49ers and defy the odds? Fresh off a key divisional win, the Jags face a tough road test against an injured but still dangerous Niners team. With star players sidelined, San Francisco is vulnerable, but Jacksonville's own offensive struggles and coast-to-coast travel make them underdogs. Is this the week Trevor Lawrence and the offense finally click, or will the 49ers prove too much to handle?
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