The Jacksonville Jaguars dominated the Chargers, winning thirty-five to six, marking the Chargers worst loss under coach Jim Harbaugh. The Jaguars ground game and pass rush overwhelmed the Chargers, who struggled offensively, managing only two field goals. Quarterback Justin Herbert was under constant pressure, spending time in the medical tent, and was eventually replaced by backup Trey Lance in the fourth quarter. The Chargers offensive line, particularly new left tackle Trevor Penning, struggled in his debut.
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