Guest:
Dr. Carole LaBonne is the Erastus Otis Haven Professor of Molecular Biosciences at Northwestern University. Her lab studies the genesis of neural crest stem cells at the level of the signaling pathways and transcription factors that comprise the neural crest gene regulatory network. They also study how these mechanisms contribute to exit from pluripotency and the subsequent lineage restriction of neural crest cells to their derivative cell types that collectively define vertebrates. (39:45)
Creating Modified Cows and Sheep from Haploid Stem Cells – Scientists have successfully derived haploid androgenetic ESCs from cattle and sheep, and have developed a novel method to generate offspring from these cells. (4:33)
Embryonic Stem Cells from Birds – Researchers have succeeded in deriving and maintaining authentic ESCs from chickens and seven other bird species. (13:48)
Mutation Hotspots Reveal Spermatogonia Clonal Growth – As men age, harmful genetic mutations in sperm not only accumulate but are also favored during sperm production, giving them a reproductive advantage. (20:35)
Canine iPSC Technology – Researchers have established culture conditions for canine iPSCs. (31:10)
Photo Reference: Courtesy of Dr. Carole LaBonne
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