Description

Join us this week as we discuss whether or not levetiracetam (Keppra) can be given as an undiluted push, straight out of the vial. Don't forget to check out our website (ERRxpodcast.com) and leave us a comment!

References:

Brophy, G. M., et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012; 17 (1): 3-23

Moheet, A. M., et al. Standards for neurologic critical care units: a statement for healthcare Professionals from The Neurocritical Care Society. Neurocrit Care. 2018; 29 (2): 145-160

Keppra (levetiracetam) [prescribing information]. Columbus, OH: West-Ward Pharmaceuticals; 2017

Burakgazi E, et al. The safety and tolerability of different intravenous administrations of levetiracetam, bolus versus infusion, in intensive care unit patients. Clinical EEG and Neuroscience. 2014; 45 (2): 89–91

Wheless JW, et al. Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution: a safety study.  J Child Neurol. 2009; 24 (8): 946-951

Dalziel S, et al. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. Lancet. 2019; 393: 2135–45

Disclaimer: 
The information contained within the  ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution,  seek medical advice from a licensed physician,  and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of,  any medical institutions, educational facilities, or other healthcare programs.

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Disclaimer:

The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.