In this episode I speak with my nephrology mentor Dr. Alan Segal. We focused this discussion on the topic of TONICITY disorders and understanding the physiology of water homeostasis in health and disease. If you've been confused by hyponatremia then you will really enjoy this discussion. Alan had slides and also presents his 2021 ASN poster (hot off the press) on a non-linear correction for [Na] in the setting of hyperglycemia. Enjoy!!