Naltrexone is an opiate antagonist used since 1984 in treating opiate addiction (preventing euphoric feelings) and alcoholism. During the last few years, Naltrexone used in low doses (Named Low Dose Naltrexone) earned favor as a novel medication that may be used in depression treatment.
Major Depressive Disorder symptoms:
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https://www.welltopiarx.com/compounding/the-potential-of-low-dose-naltrexone-in-treating-depression/