- Trade – Apresoline
- Class – Vasodilator
- MOA – Directly dilates peripheral blood vessels
- Indication – HTN associated with preeclampsia and eclampsia, HTN crisis
- Contraindication – Patients taking diazoxide or MAOI’s, coronary artery disease, stroke, angina, dissecting aortic aneurism, mitral valve and rheumatic heart disease.
- Side effects – Headache, angina, flushing, palpitations, reflex tachycardia, anorexia, N/V, diarrhea, hypotension, syncope, peripheral vasodilation, peripheral edema, fluid retention, pareshesias.
- Dosing
Preeclampsia and eclampsia:
Adult : 5-10mg IV repeat every 20-30mins until Systolic pressure of 90-105mmhg
Acute HTN ( not associated with preeclampsia )
Adult :10-20mg IV/IM
Pedi : 1mo – 12yr 0.1-0.2 mg/kg IV/IM max 20mg per dose
