An attempt to genetically re-engineer the measles virus to cure cancer becomes lethal, infecting 99% of the world's population, turning those it does not kill into vampiric, albino, cannibalistic mutants called Darkseekers, who are extremely vulnerable to sunlight and prey on the few who are left unaffected.
Three years after the outbreak, in 2012,[8] U.S. Army virologist LTC Robert Neville lives an isolated life in deserted Manhattan, unsure if any other uninfected humans are left. Neville's daily routine includes experimenting on infected rats to find a cure for the virus, searching for food and supplies, and waiting each day for any survivors who might respond to his continuous recorded radio broadcasts, which instruct them to meet him at midday at the South Street Seaport. Flashbacks reveal his wife, Zoe, and daughter, Marley, died in a helicopter accident during the chaotic evacuation of Manhattan as the military was enforcing a quarantine of the island. Neville himself stayed behind with other military personnel. Neville's only companion is his German Shepherd Samantha (Sam) and to cope with his loneliness, he regularly "talks" to some mannequins and the characters on film recordings from video stores. At night, he barricades himself with Sam inside his heavily fortified Washington Square Park home to hide from the Darkseekers.
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