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What’s driving Denver’s spike in fentanyl overdoses, and why does the supply seem stronger than ever? We take you inside the data and the street-level realities: how potency, low production costs, and distribution through a regional transit hub have reshaped the market; why counterfeit pills and polysubstance mixes catch people off guard; and how improved testing revealed the true scale of the problem. From emergency calls to hospital bedsides, you’ll hear how the human impact shows up across families, first responders, and public services.

We share the concrete steps the city is taking under Mayor Mike Johnston’s leadership, blending public health with focused enforcement. That includes expanding naloxone access, distributing fentanyl test strips, supporting syringe services, and increasing low-barrier treatment for opioid use disorder through city clinics, hospitals, and mobile outreach. Public health alerts now flag dangerous batches and counterfeit pills, while investigations target major suppliers. Progress is measurable—more reversals, more treatment access, tighter coordination—but challenges remain: volatile supply, stubborn stigma, and limited capacity slow the pace of change.

Then we pivot to schools, where substance use trends have evolved alongside vaping and high-THC products. Denver-area districts are moving beyond zero tolerance toward approaches that work: evidence-based education, screening and brief intervention, onsite clinicians, family engagement, and restorative discipline that keeps students connected to support. Staff training in naloxone and practical harm reduction messages meet the moment, while data-driven monitoring helps schools adapt to new products and risks. The path forward is clear and compassionate: prevention that resonates, treatment that’s accessible, and enforcement focused on harms, not headlines.

If this conversation helped you think differently about fentanyl and youth substance use, subscribe, share with a friend, and leave a review to help others find the show.

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