In this engaging episode recorded at the second annual Peds GI Connect in Hollywood, Florida, Dr. Carlo Di Lorenzo, pediatric gastroenterologist at Nationwide Children’s Hospital, is joined by Kate Scarlata, MPH, RDN, and Dr. Ankur Chugh from Children’s Wisconsin for a deep dive into sucrase-isomaltase deficiency (SID)—a condition gaining traction in both clinical and public awareness. Together, they explore how SID, previously thought to be rare and limited to congenital forms, is increasingly recognized in both children and adults as a contributor to unexplained gastrointestinal symptoms like bloating, gas, diarrhea, and abdominal pain. The discussion breaks down diagnostic tools—from disaccharidase enzyme assays to the sucrose challenge—and outlines the nuances of dietary management, enzyme therapy, and the role of registered dietitians in tailoring treatment. The episode also highlights how SID can mimic IBS or DGBI and emphasizes the importance of avoiding overly restrictive diets in children. With real-world insights, practical tips, and a shared decision-making approach, this conversation is essential for clinicians, dietitians, and caregivers interested in the evolving landscape of carbohydrate digestion disorders and personalized GI care.
