You’re eating clean.
You’re exercising regularly.
You’re disciplined, motivated, and doing exactly what you’ve been told to do.
So why isn’t the scale moving?
In this episode of the Dr. Lori Integrative Medicine Podcast, Dr. Lori explains why weight loss resistance is one of the most common — and misunderstood — health issues today, especially for women over 35 and high-performing adults.
If you’ve been stuck thinking “This used to work, but now it doesn’t,” this episode will change how you understand your body.
This isn’t about eating less or working harder.
It’s about hormones, inflammation, stress physiology, toxins, gut health, sleep, and metabolic adaptation — the real drivers of fat loss that are often ignored.
In this episode, Dr. Lori breaks down:
Why calorie restriction can actually slow fat loss
How cortisol, thyroid dysfunction, and insulin resistance block progress
The role of perimenopause and menopause in changing metabolism
Why inflammation and toxin exposure keep the body in fat-storage mode
Which labs actually matter when weight won’t budge
What to do differently if you’re “doing everything right”
This episode is for anyone who feels frustrated, blamed, or dismissed when weight loss stalls — and is ready for a smarter, root-cause approach.
00:00 – Introduction
Why weight loss resistance is not a willpower problem
02:15 – “I’m Doing Everything Right” Syndrome
Why disciplined people struggle the most with stalled weight loss
05:40 – Why Calories In vs. Calories Out Fails
How metabolic adaptation slows fat loss over time
09:30 – Cortisol, Stress, and Fat Storage
Why chronic stress keeps your body in survival mode
13:45 – Thyroid Function and Reverse T3
Why “normal” thyroid labs can still mean a sluggish metabolism
18:10 – Insulin Resistance You Can’t See
How blood sugar and insulin block fat loss even without diabetes
22:50 – Leptin Resistance and Hunger Signals
Why your body stops responding to fullness cues
27:15 – Perimenopause, Menopause, and Weight Gain
How hormonal shifts change the rules after 35–40
32:40 – Inflammation and Weight Loss Resistance
Why your body won’t release fat when it’s inflamed
36:55 – Toxins, Mold, and Metabolism
How environmental exposures quietly disrupt hormones and fat burning
41:30 – The Labs That Actually Matter
What to test when weight loss stalls
46:10 – What to Do Instead
A smarter, integrative approach to fat loss
50:00 – Final Takeaway
Why your body isn’t broken — it’s protecting you
If this episode resonated with you:
Subscribe to the Dr. Lori Integrative Medicine Podcast
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Share this episode with someone who feels stuck and discouraged
Visit Dr. Lori Integrative Medicine to learn how functional labs can uncover your root cause
You don’t need more discipline.
You need better data — and a better plan.
