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The Web is increasingly be used as the threat vector of choice by hackers and cybercriminals to distribute malware and perpetrate identity theft, financial fraud, and corporate espionage.  Is exploit sophistication and complexity evolving beyond traditional endpoint anti-virus mitigation?  Is a network centric model a faster and more accurate approach to zero day threat defense where massive cloud computing resources are put to work identifying and mitigating complex, polymorphic threats designed to evade anti-virus software are mitigated before they reach desktop or mobile endpoints?  Mark Guntrip, Product Manager at Cisco Systems joins me to discuss Cisco ScanSafe, a Cloud Web Security Offering and debate client versus network based zero day threat defense.