Giancana was born in Chicago to Italian immigrant parents. He joined the 42 Gang as a teenager, developing a reputation in organized crime which gained him the notice of Chicago Outfit leaders. During the late 1930s, Giancana joined the Chicago Outfit. From the 1940s through the 1950s, he controlled the illegal gambling, illegal liquor distribution, and political rackets in Louisiana. In the early 1940s, Giancana was involved in Chicago's African-American lottery payout system for the Outfit. In 1957, Giancana became the boss of the Chicago Outfit.