The gut-immune axis is one of the most important and most overlooked systems in human health. In this episode of Revolution Health Radio, Chris explains how the gut microbiome, intestinal barrier, and immune system work together to regulate inflammation and protect against disease. Learn how disruptions in gut health, driven by ultra-processed foods, environmental toxins, antibiotics, and chronic stress, can lead to intestinal permeability, chronic immune activation, and a wide range of conditions including autoimmune disease, skin disorders, respiratory illness, and metabolic dysfunction. Chris also breaks down the latest research on key compounds that support gut and immune health, including probiotics, prebiotics, butyrate, polyphenols, colostrum, lactoferrin, and beta glucan. Discover how targeted nutrition and lifestyle strategies can restore gut integrity, improve immune resilience, and address the root cause of chronic illness.
In this episode we discuss:
- The role of the microbiome in immune regulation
- Intestinal permeability ("leaky gut") and its systemic effects
- Lipopolysaccharides and chronic inflammation
- The link between gut dysfunction and chronic diseases
- "Inflammaging" and the gut's role in aging
- How modern life disrupts gut health
- Practical strategies to support the gut-immune axis
Show notes:
- "Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review" by Di Vincenzo, F., et al.
- "Oral supplementation with bovine colostrum decreases intestinal permeability and stool concentrations of zonulin in athletes" by Haląsa, M., et al.
- "Lactoferrin reduces the risk of respiratory tract infections: a meta-analysis of randomized controlled trials" by Ali, A. S., et al.
- "Akkermansia muciniphila and gut immune system: a good friendship that attenuates inflammatory bowel disease, obesity, and diabetes" by Rodrigues, V. F., et al.
- "Aging and inflammation" by Singh, A., et al
- "Beta-glucans: a potential source for maintaining gut microbiota and the immune system" by Singh, R. P., & Bhardwaj, A.
- "The bidirectional gut-lung axis in chronic obstructive pulmonary disease" by Wang, L., et al.
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