In this episode, John Chen, MD, PhD, joins Ogul Uner, MD, to share his experience in neuro-ophthalmology. In the case discussed, a 32-year-old woman presented with decreased vision and pain in her right eye for 1 week, and examination revealed a rapid afferent pupillary defect. The patient also mentioned she had experienced numbness in her right arm 1 year ago. Dr. Chen explains why he would suspect retrobulbar optic neuritis in this case, and what his next steps would be to confirm that diagnosis and treat the patient.