Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer
Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis
from Journal of American Medical Association
Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis
The EVOLVED Randomized Clinical Trial
Annals of Internal Medicine
Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer
Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study
British Medical Journal
Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies
Lancet
The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial
Journal of Clinical Oncology
Randomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH)
journal of Hepatology
Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH
Gastroenterology
A Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis
Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)
Clinical Infectious Diseases
Evidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections
Abstract
Rheumatology
Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center
Circulation
RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing
Journals of the American College of Cardiology
Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis
JAMA Cardiology
Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure
Journal of Clinical Endocrinology & Metabolism
Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas
Diabetes care
Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes
The American Journal of Respiratory and Critical Care Medicine
The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome
Rationale: A U-shaped relationship should exist between lung volume and Kidney International reports
Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients
A Survey on End-of-Life Contemplation Among Patients on Dialysis
