Hi, This Week in Medicine, we will be discussing
First we will be discussing articles in New England Journal of Medicine
Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C
Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes
Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes
Mirvetuximab Soravtansine in FRα-Positive, Platinum-Resistant Ovarian Cancer
Journal of American Medical Association
Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer: The ORIENT-16 Randomized Clinical Trial
Pregnancy After Breast Cancer in Young BRCA Carriers
Annals of Internal Medicine
Second-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma
Lancet
Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial
Journal of Clinical Oncology
Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer
Journal of Hepatology
Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma
Clinical Gastroenterology
Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study
Blood
Clinical Outcomes in Patients with High-Dose Methotrexate Toxicity Treated with Vs. without Glucarpidase
Clinical Infectious Diseases
Diagnostic Accuracy of Hospital Antibiograms in Predicting the Risk of Antimicrobial Resistance in Enterobacteriaceae Isolates: A Nationwide Multicenter Evaluation at the Veterans Health Administration
Journal of Clinical Rheumatology
Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib
Arthritis and Rheumatology
Poly-refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease with Distinct Inflammatory and Non-inflammatory Phenotypes
Circulation
Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study
American College of Cardiology
Long-Term Safety of Inclisiran for Treatment of Hypercholesterolemia
Journals of the American College of Cardiology
Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials
Journal of Clinical Endocrinology & Metabolism
Effective GH Replacement With Somapacitan in Children With GHD: REAL4 2-year Results and After Switch From Daily GH
Neurology:
Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis
Chest
Multiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure
The American Journal of Respiratory and Critical Care Medicine
Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study
Clinical and Translational Gastroenterology
Non-Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Non-ampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study
Clinical Journal of American Society of Nephrology
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Nurse Practitioner Care Compared with Primary Care or Nephrologist Care in Early CKD
Kidney International reports
Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy
