Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer
Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage
Journal of American Medical Association
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a)
Nature Medicine
Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers
British Medical Journal
Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study
Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial
Lancet
Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): a randomised, double-blind, phase 3 clinical trial
Journal of Clinical Oncology
Genomic Classification and Individualized Prognosis in Multiple Myeloma
journal of Hepatology
Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B
Episodic overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis
Clinical Gastroenterology
Significance of Crypt Atypia in Barrett’s Esophagus: A Clinical, Molecular, and Outcome Study
Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis
Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis
Benefits of Prokinetics, Gastroparesis Diet, or Neuromodulators Alone or in Combination for Symptoms of Gastroparesis
Clinical Infectious Diseases
Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe
Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir
SARS-CoV-2 Infection and Postacute Risk of Non–Coronavirus Disease 2019 Infectious Disease Hospitalizations: A Nationwide Cohort Study of Danish Adults Aged ≥50 Years
Journal of infectious Diseases
Journal of Clinical Rheumatology
Chronic Nonbacterial Osteomyelitis Associated With Familial Mediterranean Fever in Children
Arthritis and Rheumatology
Characterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive–Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study
Circulation
mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis
American College of Cardiology
One-Month Ticagrelor Monotherapy After PCI in Acute Coronary Syndromes
Journals of the American College of Cardiology
Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score
Journal of Clinical Endocrinology & Metabolism
Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention
Lifestyle Intervention With Smartphone App and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial
Neurology:
Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis: A Registry-Based Study
Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults
Chest
Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial
Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals
The Effect of Pressure Changes During Mechanical Insufflation-Exsufflation on Respiratory and Airway Physiology
The American Journal of Respiratory and Critical Care Medicine
SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset
Clinical Journal of American Society of Nephrology
Efficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria
Monoclonal Gammopathy and Its Association with Progression to Kidney Failure and Mortality in Patients with CKD
Kidney International reports
Implications of Implementing the 2021 CKD-EPI Equation Without Race on Managing Patients With Kidney Disease in British Columbia, Canada
Pregnancies in Women With Kidney Failure on Home Dialysis in the United States
