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Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis

 

Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis

 Journal of  American Medical Association

Spironolactone vs Amiloride for Resistant Hypertension

  Annals of Internal Medicine

Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025

  British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study

 Lancet

Clinical presentation and epidemiological assessment of confirmed human mpox cases in DR Congo: a surveillance-based observational study

  journal of Hepatology

A new generation of non-invasive tests of liver fibrosis with improved accuracy in MASLD

  Gastroenterology

 

Physiological Data Collected From Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares

 Clinical Gastroenterology

Reproducibility of the AGREE II Tool for Assessing the Methodological Quality of Clinical Practice Guidelines for the Management of Antithrombotic Agents in Patients Undergoing GI Endoscopy

 Circulation

Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes

 Journals of the American College of Cardiology

Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI: Results From the ORBITA-2 Trial

 JAMA Cardiology

Trajectory of Cardiovascular Health Across Childhood and Adolescence

 Journal of Clinical Endocrinology & Metabolism

Renal Protective Effect of Metformin in Type 2 Diabetes Patients

 Diabetes care

Efficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials of Heart Failure and Chronic Kidney Disease 

  Neurology

Endovascular Thrombectomy for Large Ischemic Core Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  Chest

Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes

 The American Journal of Respiratory and Critical Care Medicine

Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma 

 Clinical Journal of American Society of Nephrology

Dialysis Dependence in Standard versus Accelerated Initiation of KRT in AKI: A Post Hoc Analysis

 Kidney International reports

Scoping Review of Kidney Patients and Providers Perspectives on Disaster Management