Bethany and Molly kick off Season 4 with a dive into the weirdest corners of HDFN — from mind-blowing bizarre facts (like babies born with 100% donor blood and drones parachuting blood bags in Africa) to rare case studies featuring anti-Kell + anti-D, the ultra-rare anti-KU and anti-PP1P˩K antibodies, and a mystery about false-positive newborn screens that still has experts stumped.
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References in this episode:
Read more about the “grandmother effect” here where a female fetus can become exposed to her mother’s Rh(D) positive blood in utero, priming her for Anti-D sensitization: here.
Gender as a risk factor for developing neutropenia in HDFN: Alkhani A, Arefi A, AlTayeb M, Naaz S, Alghanbar J, Alhuthil R, Alrowaily F, Almidani E. Incidence and risk factors of neutropenia in neonates with hemolytic disease of the newborn. International Journal of Pediatrics and Adolescent Medicine. 2024 Sep 1;11(3):83-7. Available here.; Blanco E, Johnston DL. Neutropenia in infants with hemolytic disease of the newborn. Pediatric blood & cancer. 2012 Jun;58(6):950-2. Available here.
Read about drone delivery of blood in Rwanda: here.
Anti-PP1PK literature review and case presentations: Di Ciaccio P, Cutts B, Alahakoon TI, Dennington PM, Soo LA, Curnow J. Clinical consequences of the extremely rare anti‐PP1Pk isoantibodies in pregnancy: a case series and review of the literature. Vox Sanguinis. 2021 May;116(5):591-600.
