In this sermon on Genesis 6:1–4, we examine one of the most debated and mysterious passages in Scripture: the sons of God, the daughters of men, and the Nephilim. Set in the context of the war between the seed of the serpent and the seed of the woman, this passage reveals the final escalation of moral and biological corruption before the flood. Drawing from the Old and New Testaments, we explore historic interpretations held by the early church, the role of fallen angels, the identity of the Nephilim, and why God announced a 120-year countdown to judgment. Ultimately, this text reminds us that even when evil seems overwhelming, God remains sovereign, preserves His promised seed, and faithfully accomplishes His redemptive purposes.