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Dr. Paul Greengard, Professor of Molecular and Cellular Neuroscience at Rockefeller University, talks about his life and career with his former student Dr. Eric Nestler, Professor and Chair of Neuroscience at the Mount Sinai School of Medicine. Dr. Greengard won the 2000 Nobel Prize in Physiology or Medicine for his work on the signaling pathways in the nervous system. He and his colleagues showed nerve cells communicate through either fast or slow synaptic transmission. Dr. Greengard discusses their discoveries and the resistance and skepticism they faced when they published the results.