Listen to short summaries of the latest oncology-focused research literature published in this week's issue of Oncotarget.
https://www.oncotarget.com/archive/v12/i6/
Oncotarget Volume 12, Issue 6 features:
COVER PAPER:
"Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma."
Institutions: Washington University in St. Louis, Columbia University, St. Louis Children’s Hospital, Siteman Cancer Center
Quote: “We characterized genomic and neoantigen changes between 23 paired primary and recurrent HNSCC tumors. Twenty-three biopsies from patients originally diagnosed with locally advanced disease were identified from the Washington University tumor bank.”
doi.org/10.18632/oncotarget.27907
EDITORIAL:
"Innovating and expanding weight loss strategies for breast cancer survivors."
Institution: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Quote: “Compared to those with ideal body weight, women who have excess weight experience inferior outcomes once diagnosed with breast cancer, despite standard local and adjuvant therapy [6].”
https://doi.org/10.18632/oncotarget.27898
RESEARCH PERSPECTIVE:
"Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies."
Institutions: The Johns Hopkins University School of Medicine, Dartmouth Geisel School of Medicine and Norris Cotton Cancer Center, Yale University, Stony Brook University Renaissance School of Medicine
Quote: “Here, we review PDAC pathogenesis as it relates to fundamental ARS [Alternative RNA splicing] biology, with an extension to implications for PDAC patient clinical management.”
doi.org/10.18632/oncotarget.27901
RESEARCH PAPER:
"A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas."
Institutions: Loma Linda University, University of Kansas
Quote: “Herein we describe our search for small molecule inhibitors that disrupt binding of E6 to caspase 8 using AlphaScreen technology™ (Perkin Elmer, Waltham, MA). This technology is a proximity-based platform for identifying hit compounds that perturb a specific interaction between two beaded proteins. Using this approach, we interrogated a library of over 5000 small molecules for compounds that antagonize E6 binding to caspase 8.”
doi.org/10.18632/oncotarget.27908
RESEARCH PAPER:
"Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models."
Institution: Ghent University
Quote: “Here, we characterized the tumor microenvironment and the proportion and transcriptional profile of hepatic macrophages (Mφ) in two commonly used HCC mouse models.”
doi.org/10.18632/oncotarget.27906
RESEARCH PAPER:
"Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations."
Institutions: Tata Memorial Centre, Homi Bhabha National Institute
Quote: “We performed survival analyses of lung squamous cell carcinoma patients harboring therapeutically relevant alterations identified by whole exome sequencing and mass spectrometry-based validation across 430 lung squamous tumors.”
doi.org/10.18632/oncotarget.27905
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