Listen to a press release about the cover paper of Volume 14, Issue 13, entitled, "Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.”
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A new research paper was published in Aging (Aging-US / Albany NY) on the cover of Volume 14, Issue 13, entitled, “Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.”
“Perceived discrimination may be associated with accelerated aging later in life, with depressive symptoms acting as potential mediator.”
In this recently published study, researchers May A. Beydoun, Hind A. Beydoun, Nicole Noren Hooten, Ana I. Maldonado, Jordan Weiss, Michele K. Evans, and Alan B. Zonderman from the National Institute on Aging’s Intramural Research Program, Fort Belvoir Community Hospital, University of Maryland, and University of California Berkeley examined a nationally representative sample of 2,806 older U.S. adults. The team evaluated associations of perceived discrimination measures with 13 DNA methylation (DNAm)-based measures of epigenetic aging. They used group-based trajectory and four-way mediation analyses.
“Here we examined retrospective data from the HRS [Health and Retirement Study 2010–2016] cohort study of U.S. adults aged 50–100 years and investigated measures of perceived discrimination and depressive symptoms in relation to 13 different DNAm-based epigenetic clocks (EPICLOCK) age-estimators.”
Read the full press release - https://www.aging-us.com/news_room/epigenetic-clocks-and-their-association-with-perceived-discrimination-and-depressive-symptoms
DOI - https://doi.org/10.18632/aging.204150
Corresponding Author: May A. Beydoun – Email: baydounm@mail.nih.gov
Keywords: DNA methylation, epigenetic clocks, biological age, perceived discrimination, depressive symptoms
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About Aging-US:
Launched in 2009, Aging (Aging-US / Albany NY) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
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