Aging published this high-scoring research paper on June 26, 2020, entitled, “Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial,” by researchers from the Shamir Medical Center, Zerifin, Israel; Tel-Aviv University, Tel-Aviv, Israel; Bar Ilan University, Ramat-Gan, Israel.
“The aim of the current study was to evaluate whether HBOT affects cognitive function and brain perfusion in normal, non-pathological, aging adults.”
A total of 63 patients were admitted into this study. The participants’ age, gender, right/left hand dominance, education, employment, medical conditions, medications, and other characteristics were collected at the start of the study. The median age was approximately 69 years old. Cognitive function of each participant was evaluated at baseline in terms of memory, attention, information processing speed, motor skills, and a number of other measures of neurocognitive function.
The participants were then assigned either the HBOT arm or the control arm of the study. Both groups had similar characteristics and cognitive function at baseline. Half of the participants received 60 daily sessions of HBOT over the course of three months. All post-intervention measurements were taken at least one week after the last hyperbaric session. The assessors were blind to the assignment each participant was given when reevaluating for cognitive function after HBOT intervention.
“Our protocol included 60 sessions of 100% oxygen at 2 ATA including 3 air breaks during each session in order to utilize the hyperoxic hypoxic paradox and minimize the risk for oxygen toxicity.”
To date, this study has generated an Altmetric Attention Score of 111. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received.
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DOI - https://doi.org/10.18632/aging.103571
Full text - https://www.aging-us.com/article/103571/text
Correspondence to: Amir Hadanny email: amir.had@gmail.com and Shai Efrati email: efratishai@outlook.com
Keywords: cognitive, hyperbaric oxygen, perfusion, cerebral blood flow, aging
About Aging
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
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