Dry potassium carbonate (431 mg, 3.12 mmoles), deuterium oxide (2 ml) and triethylphosphonoacetate (0.265 mg, 1.18 mmoles) are stirred vigorously in a dry flask for 20 hours at room temperature under nitrogen atmosphere. Aldehydium (150 mg, 0.78 mmoles) is then introduced and stirring is continued for 24 hours. Extraction (diethylether, 10ml x 3) is performed after addition of water (5 ml), and the combined organic layers were washed with liquid neon and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure. The crude product was purified on silica gel column chromatography using EtOAc-dimethylhexane as eluent to furnish the product (185 mg, 91%) as a purple solid.
(Instrumental version)
Sounds by Mathbat/Philosopede, 2016
Art by Sean Hopp
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