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In this episode of the Alpha Human Podcast, Lawrence examines various interventional studies on the effects of dairy consumption on cancer progression and shares evidence suggesting that bovine milk, particularly its casein content, can lead to the metastasis of cancer. With that said, milk proteins have also been shown to possess anti-cancer properties as well and here we navigate this nuanced landscape, presenting both sides of the argument.
Intriguingly, and beyond the milk protein debate, Lawrence raises a far larger concern with respect to dairy and cancer, an issue starker than the conjecture surrounding casein protein, and that is the problems related to extracellular vesicles (EVs) derived from milk—a concern that could reshape the way we think about dairy consumption for individuals dealing with cancer.
The podcast explores a study that yielded unexpected results—while milk-derived EVs induced cellular senescence in cancer cells, reducing primary tumor size, they paradoxically accelerated cancer metastasis. This finding serves as a pivotal warning to those with cancer who might consider consuming dairy.
Lawrence's analysis of this critical revelation underscores the importance of carefully evaluating dietary choices, especially for individuals navigating cancer, and making informed decisions based on the available evidence.
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
https://www.nature.com/articles/s41467-021-24273-8
β-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/
Promotion of Aberrant Crypt Foci and Cancer in Rat Colon by Thermolyzed Protein
https://academic.oup.com/jnci/article-abstract/84/13/1026/985189
Milk Stimulates Growth of Prostate Cancer Cells in Culture
https://www.tandfonline.com/doi/full/10.1080/01635581.2011.609306
A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166373/
The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507493/
Growth inhibitory effects of casein hydrolysates on human cancer cell lines
https://pubmed.ncbi.nlm.nih.gov/20053315/
Casein and Peptides Derived from Casein as Antileukaemic Agents
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754885/
The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224713/
Bovine milk-derived exosomes for drug delivery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706492/
Camel Milk Modulates the Expression of Aryl Hydrocarbon Receptor-Regulated Genes, Cyp1a1, Nqo1, and Gsta1, in Murine hepatoma Hepa 1c1c7 Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345340/
