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It would not surprise us if we saw a new wave of ecological horror in which our own mistreatment of the environment and our irresponsible handling of pharmaceutical progress creates flesh hungry critters, pissed off two-headed bears, opioid addicted tapeworms, whatever. Let’s prepare by looking over history’s forewarnings, shall we?

Here are our favorite mutant animal films—cautionary tales about big pharma, careless planet keeping and sex.