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Genesis 3:15(NIV)

“He will crush[b] your head,
    and you will strike His heel.” 

Genesis 12:1,3(NIV)
“The Lord had said to Abram, “Go from your country, your people and your father’s household to the land I will show you…in you all the families of the earth shall be blessed.”

Genesis 22:1-2(ESV) 

God tested Abraham and said to him, “Abraham!” And he said, “Here I am.” 2 He said, “Take your son, your only son Isaac, whom you love, and go to the land of Moriah, and offer him there as a burnt offering on one of the mountains of which I shall tell you.” 

Genesis 22:1-2(ESV) 

God tested Abraham and said to him, “Abraham!” And he said, “Here I am.” 2 He said, “Take your son, your only son Isaac, whom you love, and go to the land of Moriah, and offer him there as a burnt offering on one of the mountains of which I shall tell you.” 

John 1:14(NIV)
“The Word became flesh and made his dwelling among us. We have seen his glory, the glory of the one and only Son, who came from the Father, full of grace and truth.

John 3:16(NIV)
For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life.

“go to the land of Moriah”

“offer him (Isaac) there as a burnt offering on one of the mountains of which I shall tell you.” 

Gen. 22:3-6(ESV)
So Abraham rose early in the morning, saddled his donkey, and took two of his young men with him, and his son Isaac. And he cut the wood for the burnt offering and arose and went to the place of which God had told him. 4 On the third day Abraham lifted up his eyes and saw the place from afar. 5 Then Abraham said to his young men, “Stay here with the donkey; I and the boy[a] will go over there and worship and come again to you.” 6 And Abraham took the wood of the burnt offering and laid it on Isaac his son. And he took in his hand the fire and the knife. So they went both of them together. 

“(We will) come again to you.”

“Abraham took the wood of the burnt offering and laid it on Isaac his son”

Genesis 22:7(ESV)
And Isaac said to his father Abraham, “My father!” And he said, “Here I am, my son.” He said, “Behold, the fire and the wood, but where is the lamb for a burnt offering?” 

Genesis 22:8(ESV)
Abraham said, “God will provide for himself the lamb for a burnt offering, my son.” So they went both of them together.

Genesis 22:9(ESV)
When they came to the place of which God had told him, Abraham built the altar there and laid the wood in order and bound Isaac his son and laid him on the altar, on top of the wood. 

Genesis 22:10-12(ESV)
Then Abraham reached out his hand and took the knife to slaughter his son. 11 But the angel of the Lord called to him from heaven and said, “Abraham, Abraham!” And he said, “Here I am.” 12 He said, “Do not lay your hand on the boy or do anything to him, for now I know that you fear God, seeing you have not withheld your son, your only son, from me.” 

Genesis 22:13(ESV)

And Abraham lifted up his eyes and looked, and behold, behind him was a ram, caught in a thicket by his horns. And Abraham went and took the ram and offered it up as a burnt offering instead of his son. 

Galatians 3:16(NIV)
“The promises were spoken to Abraham and to his seed. Scripture does not say “and to seeds,” meaning many people, but “and to your seed,”[a] meaning one person, who is Christ."