In this episode of the SuperCreativity Podcast, James Taylor speaks with Professor Masud Husain, neurologist, neuroscientist, essayist, and author of Our Brains, Ourselves: What a Neurologist's Patients Tell Him About the Brain. A leading researcher at the University of Oxford, Husain explores how the brain constructs our sense of self—and what happens when that system breaks down.
Through remarkable patient stories—from a man who loses his motivation after a stroke to a woman whose hand acts with a mind of its own—Husain shows how identity, motivation, and consciousness emerge from the fragile architecture of the brain. Together, they discuss the neuroscience of apathy and addiction, the role of dopamine in behavior, the intersection of AI and neurobiology, and what it truly means to be human.
If you've ever wondered how much of "you" is shaped by your brain—and how much you can change—this conversation offers profound insights into the science of the self.
The brain builds identity — Selfhood arises from multiple interacting functions: memory, motivation, attention, and perception.
Apathy and addiction share the same circuitry — Dopamine links motivational cues to action; too little or too much disrupts balance.
Motivation can be restored — Dopaminergic treatments show promise for patients whose "will to act" has vanished after brain injury.
Attention is selective and limited — The brain filters vast sensory input, sustaining focus through the right hemisphere's networks.
We remain flexible — Even in adulthood, the brain's plasticity allows for self-directed change in habits, motivation, and mindset.
"Our brains create our identities—ourselves. And when a part of that function fails, so does a piece of who we are." – Prof. Masud Husain
"Motivation is not just psychological—it's biological. It lives in deep circuits that connect desire to action." – Prof. Masud Husain
"Apathy and addiction are two sides of the same coin—they both involve the brain's motivation system gone wrong." – Prof. Masud Husain
"We can still learn and reshape who we are. Even in adulthood, the brain remains astonishingly flexible." – Prof. Masud Husain
00:00 – Introduction to Professor Masud Husain and Our Brains, Ourselves
01:24 – How neurological patients reveal the building blocks of identity
03:18 – Why the self is a neuro function, not a philosophical abstraction
05:24 – The brain as a "controlled hallucination" machine
06:57 – Case study: David, apathy, and the basal ganglia
09:54 – Dopamine, motivation, and recovery through treatment
14:35 – Oxford study on apathy and brain activation differences
16:23 – Apathy vs. addiction: the same motivation circuitry at work
19:02 – Dopamine as the "wanting" transmitter, not the pleasure chemical
21:52 – Attention, distraction, and why focus is so difficult to sustain
24:50 – How Marvin Minsky's "society of mind" shaped modern neuroscience
27:55 – The illusion of self: from Descartes to Buddhist philosophy
30:12 – Case study: Anna's "alien hand" and body representation in the brain
33:38 – Phantom limbs, body maps, and how tools become part of us
36:01 – When machines become extensions of the self
37:41 – How adults can retrain motivation and change behavior
39:26 – Why the brain's plasticity offers lifelong potential for growth
40:05 – Book recommendation: Principles of Neuroscience by Eric Kandel
40:46 – Where to learn more: masudhusain.org
Book: Our Brains, Ourselves
Website: masudhusain.org
Recommended Read: Principles of Neuroscience by Eric Kandel and James Schwartz
