The Indianapolis Colts head into their matchup against the San Francisco 49ers with an interesting storyline at quarterback. Philip Rivers has never lost to the 49ers, holding a 4–0 career record against San Francisco, and he’s historically played some of his best football against them.
The 49ers come in hot after a strong Week 15 performance, powered by one of the league’s top offenses. Meanwhile, the Colts are looking to bounce back and prove they can hang with an NFC contender. This game sets up as a clash between elite offensive firepower and a Colts team fighting to stay competitive late in the season.
Can Rivers keep his perfect record alive, or will the 49ers finally flip the script? We break down the matchups, key players, and what to watch for in this must-see showdown.
