Join us in this fascinating episode where we converse with Dr. Thomas Armbruster on his innovative research in neurobiology. The episode dives deep into the intricacies of astrocyte-neuron interactions and the unique role that astrocytes play in neuronal activity.
Astrocytes, a type of glial cell, are known to interact with neuronal synapses through their distal processes, aiding in the removal of glutamate and potassium (K+) post-neuronal activity. These actions are dependent on astrocyte membrane potential (Vm). Interestingly, while astrocyte Vm has long been considered largely static, Dr. Armbruster’s research paints a different picture.
By utilizing genetically encoded voltage indicators, Dr. Armbruster's team measured Vm at peripheral astrocyte processes (PAPs) in mice. They discovered large, quick, focal, and pathway-specific depolarizations in PAPs during neuronal activity. These depolarizations, driven by presynaptic K+ efflux and electrogenic glutamate transporters in response to neuronal activity, inhibited astrocyte glutamate clearance.
This finding unveils a new dimension of astrocyte-neuron interaction, with astrocyte depolarization enhancing neuronal activation by glutamate. Such an intricate form of astrocyte-neuron interaction represents a novel class of subcellular astrocyte membrane dynamics, opening up fresh avenues in our understanding of neurobiology.
Join us as we discuss these intriguing findings and their implications for the future of neuroscience.
Keywords: Dr. Thomas Armbruster, Astrocytes, Neurons, Glutamate Clearance, Membrane Potential, Neurobiology, Peripheral Astrocyte Processes, Depolarization, Glial Cells, Neuronal Activation.
https://doi.org/10.1038/s41593-022-01049-x Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes
