God's holiness, more than any other of His attributes, exposes our miserable failure as human beings. Although we are created in the image of the holy God, we are hopelessly incompetent at living holy lives, thus we hide from God's holiness and like Adam and Eve, we try to find way of covering our sin by convincing ourselves that we have a righteousness that some how commends us to God.
The holiness of God is nothing to be trifled with. As with Isaiah and others who followed him, god's holiness should cause us to tremble. The apostle John writes in Revelation 15:4 "Who will not fear, O Lord, and glorify Thy name? For Thou alone art holy", it is to God's holy name that we are to give thanks.