Description

In this episode, we delve into Parvovirus B19: What does it do? How does it affect the joints? How was it discovered? Does it only infect young female schoolteachers? Find out!

Brought to you by Actemra

• Intro :12
• Shout out to Cleveland Clinic Biologic Therapies Summit 1:22
• In this episode 2:11
• An overview of the virus 3:46
• What causes the aplastic crisis? 6:16
• What does the virus do in humans? 11:46
• A two-phase trial on young adults 14:29
• A summary of studies 18:55
• So, what happens to these patients? 22:59
• How about a long-term study? 24:39
• Summing up Parvovirus 19 26:42
• The big takeaway from this episode 27:33
• The next episode 28:06

Disclosures: Brown reports no relevant financial disclosures.

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Anderson MJ, et al. J Infect Dis. 1985;152:257-265.

Chorba T, et al. J Infect Dis. 1986;154:383-393.

Moore TL. Curr Opin Rheumatol. 2000;12:289-294.

Mortimer PP. Nature. 1983;302:426-429.

Ogawa E, et al. J Infect Chemother. 2008;14:377-382.

Potter CG. J Clin Invest. 1987;79:1486-1492.

Reid DM, et al. Lancet. 1985;1:422-425.

Speyer I, et al. Clin Exp Rheumatol. 1998;16:576-578.

Takahashi Y, et al. Proc Natl Acad Sci USA. 1998;95:8227-8232.

White DG, et al. Lancet. 1985;1:419-421.

Young N, et al. J Clin Invest. 1984;74:2024-2032.

Young NS, Brown KE. N Engl J Med. 2004;350:586-597.