Dr. Sepideh Abdi reviews the key imaging features of premalignant bone and soft-tissue conditions, highlighting how radiologists can recognize early signs of malignant transformation in benign tumors and chronically injured tissues. From osteochondromas and enchondromas to neurofibromas, atypical lipomatous tumors, and radiation-induced sarcomas, this episode provides practical takeaways for identifying imaging findings that warrant  closer evaluation and intervention.