We break down the mechanism of action for GLP-1 receptor agonists like tirzepatide (Zepbound/Mounjaro) and semaglutide, explaining how these medications work in the body to regulate appetite and metabolism.
• GLP-1 medications contain a C20 fatty diacid that binds to albumin, prolonging half-life
• These drugs target both GIP and GLP-1 receptors to regulate appetite and caloric intake
• Receptors are found in brain areas involved in appetite regulation and throughout the GI system
• Pharmacodynamics include increased insulin sensitivity, reduced glucagon secretion, and delayed gastric emptying
• Medications are absorbed subcutaneously with about 80% bioavailability
• Distribution occurs throughout the body with 5-6 day half-life, explaining weekly dosing
• Metabolism occurs primarily through the liver with excretion via urine
• Common injection sites include arms, legs, stomach, or back (the "margarita" zones)
Never do this on your own without real supervision. Everything has to be done safely, with a healthcare provider and someone that is aware of where you stand and how you are.
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