The Cancer Advances Podcast welcomes back Nathan Mesko, MD, Vice Chair of Global Clinical Operations for the Department of Orthopaedic Surgery and Center Director for Musculoskeletal Oncology at Cleveland Clinic to talk about chemotherapy, limb salvage surgery and how 3D printed custom implants are reshaping outcomes in osteosarcoma. Dr. Mesko also shares a remarkable pediatric case whose complex reconstruction highlights the power of multidisciplinary care, surgical innovation and long term functional recovery.