In this episode, we explore the complex world of gastroparesis. Gastroparesis is a condition that slows the stomach’s ability to empty food and turns mealtime into a daily challenge. From the science behind digestion to the symptoms, causes, and evolving treatments for idiopathic gastroparesis, we break down what happens when the stomach stops cooperating. Learn how this disorder affects quality of life and what new therapies would look like to help people enjoy food again without the side effects.
References:
Parkman, H. P., Jacobs, M. R., Mishra, A., Hurdle, J. A., Sachdeva, P., Gaughan, J. P., & Krynetskiy, E. (2011). Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Digestive diseases and sciences, 56, 115-124. https://link.springer.com/article/10.1007/s10620-010-1472-2
Hasler, W. L. (2011). Gastroparesis: pathogenesis, diagnosis and management. Nature Reviews Gastroenterology & Hepatology, 8(8), 438-453. https://www.nature.com/articles/nrgastro.2011.116
Bielefeldt, K. (2012). Gastroparesis: concepts, controversies, and challenges. Scientifica, 2012(1), 424802. https://onlinelibrary.wiley.com/doi/full/10.6064/2012/424802
Syed, A. R., Wolfe, M. M., & Calles-Escandon, J. (2020). Epidemiology and diagnosis of gastroparesis in the United States: a population-based study. Journal of clinical gastroenterology, 54(1), 50-54. https://journals.lww.com/jcge/fulltext/2020/01000/advances_in_helicobacter_pylori_therapy.9.aspx
Lee, A., & Kuo, B. (2010). Metoclopramide in the treatment of diabetic gastroparesis. Expert review of endocrinology & metabolism, 5(5), 653-662. https://www.tandfonline.com/doi/abs/10.1586/eem.10.41
Puoti, M. G., Assa, A., Benninga, M., Broekaert, I. J., Carpi, F. J. M., Deganello Saccomani, M., ... & Borrelli, O. (2023). Drugs in focus: domperidone. Journal of pediatric gastroenterology and nutrition, 77(2), e13-e22 https://onlinelibrary.wiley.com/doi/abs/10.1097/MPG.0000000000003822
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