On this week's episode, we review celiac disease. We talk about what it is, and what goes wrong inside the body. We discuss the underlying genetic factors and why genetics alone aren't enough to guarantee celiac disease. We wrap up on a hopeful note, exploring new avenues to be explored in clinical research trials.
References:
Lebwohl, B., & Rubio-Tapia, A. (2021). Epidemiology, presentation, and diagnosis of celiac disease. Gastroenterology, 160(1), 63-75. https://www.gastrojournal.org/article/S0016-5085%2820%2935165-9/fulltext
Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E., Makharia, G. K., Mearin, M. L., ... & Kaukinen, K. (2019). Coeliac disease. Nature reviews Disease primers, 5(1), 3. https://www.nature.com/articles/s41572-018-0054-z
Sollid, L. M. (2000). Molecular basis of celiac disease. Annual review of immunology, 18(1), 53-81. https://www.annualreviews.org/content/journals/10.1146/annurev.immunol.18.1.53
King, J. A., Jeong, J., Underwood, F. E., Quan, J., Panaccione, N., Windsor, J. W., ... & Kaplan, G. G. (2020). Incidence of celiac disease is increasing over time: a systematic review and meta-analysis. The American journal Gastroenterology, 115(4), 507-525. https://journals.lww.com/ajg/abstract/2020/04000/incidence_of_celiac_disease_is_increasing_over.9.aspx
Kelly, C. P., Murray, J. A., Leffler, D. A., Getts, D. R., Bledsoe, A. C., Smithson, G., ... & Turner, M. (2021). TAK-101 nanoparticles induce gluten-specific tolerance in celiac disease: a randomized, double-blind, placebo-controlled study. Gastroenterology, 161(1), 66-80. https://www.gastrojournal.org/article/S0016-5085(21)00521-7/fulltext
Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.
Follow us on Social Media:
Facebook
Instagram
Twitter
LinkedIn
Tiktok
Youtube
For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com
Thank you for listening!
