In this episode Jennifer talks with Dr. Maya Barsky about the recent renaming of PCOS to PMOS (Polyendocrine Metabolic Ovarian Syndrome), what it means for diagnosis and treatment, and how this shift can empower women to better understand and manage their health.
Dr. Barsky is a double board-certified physician in Obstetrics & Gynecology and Reproductive Endocrinology & Infertility. She serves as a Lead Physician at the Center for Advanced Reproductive Services and is an Assistant Professor in the Department of Obstetrics, Gynecology, at UConn School of Medicine. Dr. Barsky also holds a Master’s degree in Clinical Investigation, where her thesis research focused on Polyendocrine Metabolic Ovarian Syndrome (PMOS). She is passionate about helping individuals and couples from all walks of life navigate their family-building journeys with compassionate, evidence-based care.
Her clinical interests include PMOS, reproductive surgery, diminished ovarian reserve, recurrent pregnancy loss, fertility preservation, and third-party reproduction.
Key topics discussed:
- Why PCOS was renamed to PMOS (Polyendocrine Metabolic Ovarian Syndrome) and what the new name better reflects about the condition.
- The history of the condition from Stein-Leventhal syndrome (1935) through its evolution as an endocrine, metabolic and genetic disorder.
- The three diagnostic criteria for PMOS (hyperandrogenism, polyfollicular ovaries/elevated AMH, and irregular cycles) and why only two of three are needed for diagnosis.
- How PMOS affects the whole body throughout life, including endocrine, metabolic, cardiovascular, mental health and reproductive systems, not just during reproductive years.
- Why up to 70% of women were diagnosed late under the previous name, and the challenges of diagnosing PMOS in adolescents and in women approaching menopause.
- PMOS and fertility: why it is not a diagnosis of infertility, how irregular ovulation affects conception, and the range of treatment options from lifestyle changes to letrozole, IUI and IVF.
- The role of lifestyle changes in managing PMOS: high-protein diet, reduced carb load, at least 150 minutes of movement per week, hydration and sleep.
- GLP-1 medications (Ozempic, Wegovy, Zepbound) and their potential benefits for PMOS, and why they must be discontinued 1–2 months before trying to conceive.
- Supplements for PMOS: the importance of prenatal vitamins with folic acid for those trying to conceive, and inositol as an alternative to metformin.
- Dr. Barsky’s message to women who suspect they may have PMOS: there is no “typical” PMOS patient, the condition is not your fault and every woman deserves a clear diagnosis and a whole-person care plan
Resources Mentioned:
Connect with Dr. Maya Barsky
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Disclaimer: The Cycles and Seasons podcast is for general educational and informational purposes only and should not be taken as medical advice, diagnosis or treatment. Please consult your healthcare professional regarding any symptoms or medical problems you are experiencing.
