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In this fascinating episode of Heliox, we explore a groundbreaking discovery that sounds almost too sci-fi to be true: using xenon gas to fight Alzheimer's disease. Our hosts unpack recent research from Science Translational Medicine that reveals how this noble gas, commonly known for its use in bright signs and anesthesia, might hold the key to protecting our aging brains. Through engaging dialogue, we break down the complex science of how xenon influences brain immune cells called microglia, orchestrating a remarkable chain reaction that could help combat this devastating disease. The episode features insights from leading experts, including Jessica Rexach from UCLA and Jonathan Kipnis from Washington University, who help contextualize these exciting findings. We also discuss the ongoing clinical trials at Brigham and Women's Hospital, where researchers are taking the first steps toward translating these promising mouse studies to human treatments. Whether you're a science enthusiast, healthcare professional, or someone affected by Alzheimer's, this episode offers hope and illuminates the unexpected ways scientific curiosity can lead to potential breakthroughs in treating neurodegenerative diseases.

Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy

Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized 129Xe-MRI-based 8-Month Follow-Up

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This is Heliox: Where Evidence Meets Empathy

Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter.  Breathe Easy, we go deep and lightly surface the big ideas.

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Disclosure: This podcast uses AI-generated synthetic voices for a material portion of the audio content, in line with Apple Podcasts guidelines.

We make rigorous science accessible, accurate, and unforgettable.

Produced by Michelle Bruecker and Scott Bleackley, it features reviews of emerging research and ideas from leading thinkers, curated under our creative direction with AI assistance for voice, imagery, and composition. Systemic voices and illustrative images of people are representative tools, not depictions of specific individuals.

We dive deep into peer-reviewed research, pre-prints, and major scientific worksβ€”then bring them to life through the stories of the researchers themselves. Complex ideas become clear. Obscure discoveries become conversation starters. And you walk away understanding not just what scientists discovered, but why it matters and how they got there.

Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter. Breathe Easy, we go deep and lightly surface the big ideas.

Spoken word, short and sweet, with rhythm and a catchy beat.
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