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ASTRO has recently updated guidelines for post mastectomy radiotherapy (PMRT) to align practice with outcomes from multiple newly published studies for locally advanced breast cancer published over the past decade. This podcast, led by Melissa Pulfer Mitchell, MD, features lead authors of the new ASTRO PMRT guidelines Kathleen C. Horst, MD, and Rachel B. Jimenez, MD, and highlights the main questions answered by the new guidelines, as well as limitations of this expert consensus and lingering questions to be addressed.