Component-Resolved Diagnostics (CRD) is transforming the way we diagnose and manage food and aeroallergy. In this episode, we break down what CRD really is, how molecular allergy testing works, and how it improves clinical decision-making beyond traditional IgE and skin prick testing.
We explore:
- ✅ What CRD is and when to use it
- ✅ Benefits of molecular allergen testing over extract-based testing
- ✅ Clinical interpretation of key allergen components (Ara h 2, Cor a 9, Fel d 1 and more)
- ✅ Risk stratification for anaphylaxis using CRD
- ✅ Practical pros, limitations, and cost considerations
- ✅ When CRD really changes patient outcomes
Whether you are a paediatrician, allergist, GP with a specialist interest, immunology trainee, dietitian, nurse specialist, medical student, or healthcare professional, this episode offers practical, evidence-based insights you can apply in clinical practice tomorrow.
🔬 Precision medicine starts with precision allergy testing — let’s decode CRD together.
Sources:
- Blank, S., Bil o, M. B. & Ollert, M. (2018) Component-resolved diagnostics to direct in venom immunotherapy: Important steps towards precision medicine. Clinical and Experimental Allergy, 48(4), pp. 354–364. doi:10.1111/cea.13090.
- Eller, E. & Bindslev-Jensen, C. (2013) Clinical value of component-resolved diagnostics in peanut-allergic patients. Allergy, 68(2), pp. 190–194. doi:10.1111/all.12075.
- Flores Kim, J., McCleary, N., Nwaru, B. I., Stoddart, A. & Sheikh, A. (2018) Diagnostic accuracy, risk assessment, and cost-effectiveness of component-resolved diagnostics for food allergy: A systematic review. Allergy, 73(8), pp. 1609–1621. doi:10.1111/all.13399.
- Petersen, T. H., Mortz, C. G., Bindslev-Jensen, C. & Eller, E. (2018) Cow’s milk allergic children—Can component-resolved diagnostics predict duration and severity?. Pediatric Allergy and Immunology, 29(2), pp. 194–199. doi:10.1111/pai.12854.
- Schoos, A. M. M., Nwaru, B. I. & Borres, M. P. (2021) Component-resolved diagnostics in pet allergy: Current perspectives and future directions. Journal of Allergy and Clinical Immunology, 147(3), pp. 1164–1173. doi:10.1016/j.jaci.2020.12.640.
Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.
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