This episode focus on Cidara Therapeutics, a biotechnology company focused on developing Drug-Fc Conjugates (DFCs) using its proprietary Cloudbreak® platform, culminating in its acquisition by Merck (known as MSD outside the US and Canada). Cidara's lead candidate, CD388, a long-acting antiviral for influenza prevention, was the core asset driving the takeover interest due to its Phase 3 trials and Breakthrough Therapy designation from the FDA. The deal, valued at $9.2 billion, allows Merck to acquire a promising non-vaccine prophylactic for the flu as it prepares for the patent expiration of its top-selling drug, Keytruda. Separately, one source discusses the market for antifungal treatments, highlighting the FDA-approved rezafungin as a major innovation, while an academic paper provides a general valuation framework for pre-revenue biopharmaceutical companies, emphasizing the role of M&A in accelerating development.
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