Thiazide diuretics have been essential in managing hypertension and remain one of the most widely prescribed drug classes today. But their value becomes clearer when you understand the “why.”
In this episode, Dr. Busti explains the mechanism of thiazides at the distal convoluted tubule, how this drives sodium handling, and why their clinical effects differ from loop diuretics. We cover the key agents — hydrochlorothiazide, chlorthalidone, indapamide, and metolazone — and discuss their use in hypertension, edema, and special populations.
Practical insights include why chlorthalidone often has stronger evidence than HCTZ, why higher HCTZ doses don’t yield more benefit, and how these agents affect electrolytes and glucose over time. We’ll also explore side effects like hyponatremia, hypercalcemia, gout exacerbation, and drug interactions with NSAIDs, lithium, and other diuretics.
This review equips clinicians to anticipate risks, use thiazides effectively in combination therapy, and counsel patients on what to expect. Whether you’re preparing for exams or refining your clinical practice, this episode helps you translate pharmacology into better patient care decisions.
Access bonus materials and downloads at https://thisiswhy.health
Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.
