In this CAPcast episode, Dr. Gladell Paner speaks with two GI and liver pathologists, Dr. William Chopp and Dr. John Hart, as they explore the use of the CAP hepatocellular carcinoma (HCC) reporting protocol in both academic and private practice settings. Tune in as Dr. Chopp discusses the evolution of HCC reporting standards and how the protocol adapts to new data. Dr. Hart shares insights on synoptic reporting's role in standardizing cancer care and the importance of accurately subtyping HCC to guide clinical decisions. They also delve into molecular testing, multifocality, satellite lesions, and the critical role of pathology in liver transplant assessments.