🧠 Hypertrophic Cardiomyopathy — A Masterclass from Eugene Braunwald 🧬
📌 Just published in NEJM (Aug 2025): a sweeping, state-of-the-art review on HCM — from Teare's first autopsy to myosin inhibitors, AI diagnostics, and gene therapy.
💥 Clinical insights, historical depth, trial data (EXPLORER-HCM, SEQUOIA-HCM, VALOR-HCM), and future-facing advances—all distilled into one must-read.
📉 SCD prevention, 🫀 LVOT obstruction, 🧪 MYBPC3/MYH7 mutations, 🧬 proteomics, and more.
🔗 Essential reading for cardiologists, geneticists, and translational scientists.
#HCM #Braunwald #NEJM #Cardiology #PrecisionMedicine #Mavacamten #Aficamten #GeneTherapy #MedicalEducation #SCDprevention
