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🧬 Mesenchymal Drift: A New Hallmark of Aging & Disease 🧬

Researchers uncover that Mesenchymal Drift (MD)—the widespread activation of mesenchymal genes across tissues—is a conserved feature of aging and multiple diseases.

📉 High MD = worse outcomes (e.g., in Idiopathic Pulmonary Fibrosis, survival dropped from 1,027 to 294 days).

🔄 Excitingly, partial reprogramming with Yamanaka factors (OSKM) reverses MD before cells lose their identity, restoring youthful transcriptional programs.

✨ This opens the door to new therapeutic strategies for rejuvenation and age-related diseases.

#Aging #Longevity #Epigenetics #RegenerativeMedicine #CellBiology