🧬 Clonal haematopoiesis (CH)—especially with DNMT3A-R882 mutations—increases with age and raises leukemia risk.
💊 New studies reveal that metformin targets mutant blood stem cells by suppressing mitochondrial metabolism, sparing healthy cells.
📉 UK Biobank data shows lower CH prevalence in metformin users.
🔋 Targeting oxidative phosphorylation may offer a safe, preventative strategy against CH progression.
